Biologically relevant motifs

Author: bmzp

August undefined, 2024

WebMay 11, 2004 · Whether we can define modules in a stringent biologically relevant fashion is not just important for our understanding of the organization of biological systems. Many authors have conjectured that if modules are real they may also be more likely to contain proteins that are essential to viability. ... In the case of the 5' motifs, the statistic ... WebOct 18, 2024 · Below the two exons, the motifs are represented by the PDB structures of 3MJH and 1WJ0, mapped using HHPRED. ... However, some alternative protein isoforms are also biologically relevant 34,35 ...

Frequent subgraph mining for biologically meaningful structural …

WebFeb 7, 2008 · We conclude that many biologically relevant motifs appear heterogeneously distributed in the promoter region of genes, and therefore, that non-uniformity is a good indicator of biological relevance and can be used to complement over-representation tests commonly used. In this article we present the results obtained for the S. cerevisiae data … Webcommon motifs "annotated" with biologically relevant data (motifs with experimentally verified functions). It consists of three major parts (Figure 1). The central part of the project is a novel program, which is implemented by us and called "MotifScan". MotifScan differs from other motif finding programs in important ways. high court bailiff fees

An iterative statistical approach to the identification of …

WebApr 21, 2024 · The fact that these motifs represent many of the known functional components of gammaproteobacterial oriC sequences further supports the finding that … WebSep 27, 2024 · Introduction. Biopolymers, such as DNA and protein, perform varying functions based on their primary sequence. Short, repeated sequences, or “motifs” represent functional units within biopolymers that … WebNov 4, 2005 · The algorithm presented here represents an attempt to extract biologically relevant motifs based on sequence information from large-scale mass spectrometry–based data sets, and is meant to serve ... high court bail application format

Statistical signiﬁcance vs. Biological relevance

Positional motif analysis reveals the extent of specificity of protein ...

WebSep 9, 2024 · Crosslinking and immunoprecipitation (CLIP) is a method used to identify in vivo RNA–protein binding sites on a transcriptome-wide scale. With the increasing amounts of available data for RNA-binding proteins (RBPs), it is important to understand to what degree the enriched motifs specify the RNA-binding profiles of RBPs in cells. We … how fast can a blacktip shark swimWebSep 6, 2012 · This highlights a caveat in predicting expression from motifs; while we can identify biologically relevant motifs, this type of analysis only suggests a subset of factors that likely bind to a ... high court bailiffs fees

"WebAug 22, 2008 · Having chosen biologically relevant motif MHG p-value thresholds, we next compared the KMM motifs found by our motif finder for the TF-condition sets with the motifs published by MacIsaac et al. . For each TF-condition set, we allowed the motif finder to output up to five unique motifs. Only those that passed their sets' bin threshold were ... " - Biologically relevant motifs

Biologically relevant motifs

Fast and Accurate Discovery of Degenerate Linear Motifs in

WebThis can be achieved by using macrocyclization to constrain peptides into their unique and bioactive conformations. Macrocyclic-based designs of biologically relevant peptides may be informed by the patterns of hydrogen bonding observed in X-ray crystal structures. Covalent surrogates of hydrogen bonds reduce entropy by destabilizing unfolded ... WebAn important aspect is that under normal cellular concentrations, biologically relevant motifs will generally outcompete lower affinity off-target instances 38 (the implications for motif definitions based purely on …

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WebSep 27, 2024 · Moreover, pre-training with biologically relevant TFs allows single-task models in the fine-tuning step to learn useful features other than the motif of the target … WebBiologically relevant data might not show as significant in indiscriminate datasets. What seems obvious is not necessarily what has been retained in the historical process of Natural Selection.

WebMay 20, 2024 · Herein, we highlight examples of biologically relevant tertiary structures that have been successfully targeted and the strategies that yielded these promising … WebDownload Table Detailed Overview of Selected Biologically Relevant Motifs from publication: A Novel Algorithm for Enhanced Structural Motif Matching in Proteins As widely discussed in ...

WebNov 1, 2004 · We show that the module cores, the parts with the highest intramodular connectivity, are biologically relevant components of the networks. These constituents correlate only weakly with other levels of organization. ... In the case of the 5' motifs, the statistic measures the number of regulatory motifs common to at least more than half of … WebMar 16, 2024 · Fig. 5: Scope of diarylation of biologically relevant motif coupled alkynes and synthetic applications. All reactions are carried out on a 0.2 mmol scale. All the compounds are isolated as a ...

Web2 days ago · Network maps for endophenotypes in the human interactome are enriched with disease genes, further supporting the idea that disease genes form biologically relevant clusters in the broader network ...

WebDec 19, 2024 · In agreement with results on synthetic data, CNN-1’s second layer filters yielded a significantly higher match fraction of 0.845±0.012 and 0.625±0.030 to any … high court bailiffs evictionsWebMay 14, 2024 · Here we present a novel approach to identify such motifs in protein three-dimensional structures without depending on sequence alignment by representing … how fast can a blacktip reef shark swimWebJul 1, 2024 · The unique structure and biological roles of i-motifs make them attractive potential targets for small molecule binding to modulate transcriptional activity. ... In turn this will give rise to further research into aberrant modifications and subsequent impact on these biologically relevant structures within abnormal cell types. While there is ... how fast can a black footed cat runWebMay 1, 2008 · The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances. how fast can a black mamba strikeWebSep 10, 2014 · Biologically relevant linear motifs often exhibit a statistical significance that lies in or near the twilight zone (i.e. where there is a non-negligible probability to observe a random motif) . This difficulty begs for a better understanding and characterization of motif statistical significance [2] , [18] , and calls for alternative approaches. high court bail status delhiWebMar 24, 2024 · Biological motives are the driving force behind goal-oriented behaviors that result from an individual's physiological state. Some examples of biological motives are … high court bailiffs fees for evictionWebMay 16, 2024 · Identification of biologically relevant motifs from MetaChrom. To better understand what have been learned by our model, we extracted representative sequence patterns from our model using TF-MoDISco and TOMTOM (See Method 4.9). To focus on cell-type specific sequence features, we first sampled DNA sequence bins from our test … how fast can a blackhawk helicopter fly