Bitler and claudin-4
Web1 Claudin-4 Localization in Epithelial Ovarian Cancer Margaret C. Neville*, Patricia G. Webb, Heidi K. Baumgartner, Benjamin G. Bitler Margaret C. Neville, (Corresponding … WebMichael Koval, in Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease, 2024. 1.4.2.2 Claudin-4. Claudin-4 also is prominently expressed throughout the lung …
Bitler and claudin-4
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WebThe tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 ... WebMay 15, 2004 · By contrast, when claudin-3 is introduced into MDCK I cells, no change in their TER is detected. Claudin-2 thus markedly decreases the `tightness' of individual claudin-1/claudin-4-based TJ strands, providing support for the hypothesis that different combinations of claudins determine the barrier properties of individual TJ strands.
WebAug 4, 2024 · Epithelia act as a barrier between the internal and external environments, and the movement of substances via the paracellular pathway is regulated by tight junctions (TJs). Claudins are major determinants of TJ permeability. Claudin-4 was the first claudin whose involvement in the TJ permeability in cultured cells was directly demonstrated, but … WebAug 1, 2024 · Objectives: Claudin-4 is aberrantly expressed in nearly 70% of all ovarian cancer tumors, and increased claudin-4 expression conveys a worse overall survival. Poly (ADP-ribose) polymerase (PARP) inhibitors are a therapeutic option for patients with ovarian cancer. PARP inhibitors exploit deficiencies in DNA damage repair (e.g., BRCA …
WebClaudin-1 and -3 expression levels were unchanged in controls and active UC. In active UC claudin-2 mRNA was increased, whereas claudin-4 and -7 mRNA were decreased. … WebNov 1, 2005 · Abstract. The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently …
WebOct 1, 2024 · Claudin-4 phosphorylated on tyrosine 208 does not overlap with non-phosphorylated claudin-4. ... Benjamin G. Bitler was supported by Department of Defense, USA [OC170228, OC200302, OC200225], American Cancer Society [RSG-19-129-01-DDC], Division of Cancer Prevention, National Cancer Institute [R37CA261987].
WebMar 11, 2002 · Distinct from claudin-1, claudin-4 was distributed mainly in the second/third layers of stratum granulosum (a). Claudin-4 was also concentrated at the occludin-positive lines circumscribing granular cells (arrowhead) (b). SC, stratum corneum. The broken line represents the dermis/epidermis border. Bars, 20 μm. grefrath tiefbauamtWebClaudin-4 was detected at ~27 kDa using Claudin-4 Mouse Monoclonal Antibody (Product # 32-9400) at 1-3 µg/mL in 2.5 % skim milk for 3 hours at room temperature on a rocking platform. Goat Anti-Mouse IgG - HRP … grefrath treckertreffWebClaudin-4 phosphorylated on tyrosine 208 does not overlap with non-phosphorylated claudin-4. ... This work was supported by The Department of Defense (Bitler, OC170228, OC200302, OC200225), The American Cancer Society (Bitler, RSG-19-129-01-DDC), NIH/NCI (Bitler, R37CA261987). The imaging experiments were performed in the … grefrath tourismusWebMar 1, 2024 · AbstractA significant factor contributing to poor survival rates for patients with ovarian cancer is the insensitivity of tumors to standard-of-care chemotherapy. In this … grefrath trinkwassertarifWebJan 13, 2014 · Claudin-4 is a tight-junction-associated protein that is expressed in most epithelial cells but is absent in mesothelial cells. 12 Immunohistochemistry for claudin-4 has recently been shown to distinguish adenocarcinoma from malignant mesothelioma with high sensitivity and specificity, mostly in surgical specimens. 13-18 Our aim was to validate ... grefrath wassenWebHere, overexpressed claudin-4 in the jejunum and colon, coinciding with a caspase-3 decrease 72 h after 10-Gy IR exposure, can reflect the role of claudin-4 in apoptosis … grefrath webcamWebApr 1, 2024 · Knockdown of claudin-4 has recently been found to sensitize ovarian cancer cells to paclitaxel and PARP inhibitors (Breed et al., 2024, Yamamoto et al., 2024 and targeting of claudin-3 and claudin ... grefrath wankumer str